NKX3-1 monoclonal antibody, clone 361
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Specifications
Product Description
Mouse monoclonal antibody raised against full length recombinant NKX3-1.
Immunogen
Recombinant His fusion protein corresponding to full length human NKX3-1.
Host
Mouse
Reactivity
Mouse
Form
Liquid
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100)
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of NKX3-1 in mouse testis lysate with NKX3-1 monoclonal antibody (Cat # MAB2304).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry
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Gene Info — NKX3-1
Entrez GeneID
4824Gene Name
NKX3-1
Gene Alias
BAPX2, NKX3, NKX3.1, NKX3A
Gene Description
NK3 homeobox 1
Omim ID
602041Gene Ontology
HyperlinkGene Summary
The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.[supplied by OMIM
Other Designations
NK homeobox, family 3, A|NK3 transcription factor homolog A|NK3 transcription factor related, locus 1|OTTHUMP00000123534
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Interactomes
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Pathways
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Diseases
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Publication Reference
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A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.
Gao H, Ouyang X, Banach-Petrosky W, Borowsky AD, Lin Y, Kim M, Lee H, Shih WJ, Cardiff RD, Shen MM, Abate-Shen C.
PNAS 2004 Nov; 101(49):17204.
Application:WB-Ti, Mouse, Mouse prostate.
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Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.
Kim MJ, Cardiff RD, Desai N, Banach-Petrosky WA, Parsons R, Shen MM, Abate-Shen C.
PNAS 2002 Mar; 99(5):2884.
Application:IHC-P, WB-Ti, Human, Mouse, Prostate, Bladder.
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A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.
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