SGCA monoclonal antibody, clone Ad1/20A6
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More Files
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Immunohistochemistry (Frozen sections)
Immunohistochemical staining of rat skeletal muscle fibers. Note the demonstration of localized Alpha Sarcoglycan to the sarcolemma of the muscle fibers.
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Specification
Product Description
Mouse monoclonal antibody raised against SGCA.
Immunogen
Fusion protein corresponding to amino acids 217-289 of the rabbit adhalin.
Host
Mouse
Reactivity
Human, Rabbit, Rat
Specificity
Human alpha-sarcoglycan, also known as adhalin. Also crossreacts strongly with alpha-sarcoglycan in sections of muscle from rat and rabbit.
Form
Liquid
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Frozen sections) (1:100-1:200 for 60 minutes at 25°C)
The optimal working dilution should be determined by the end user.Storage Buffer
In tissue culture supernatant (0.09% sodium azide).
Storage Instruction
Store at 4°C. Do not freeze. Return to 2-8°C immediately after use. Do not use after expiration date indicated on the vial label.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Recommended positive control tissue is skeletal muscle. -
Applications
Immunohistochemistry (Frozen sections)
Immunohistochemical staining of rat skeletal muscle fibers. Note the demonstration of localized Alpha Sarcoglycan to the sarcolemma of the muscle fibers. -
Gene Info — SGCA
Entrez GeneID
6442Gene Name
SGCA
Gene Alias
50-DAG, A2, ADL, DAG2, DMDA2, LGMD2D, SCARMD1, adhalin
Gene Description
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
Gene Ontology
HyperlinkGene Summary
This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
50kD DAG|sarcoglycan, alpha
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Interactome
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Pathway
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