ABCB1 monoclonal antibody, clone 4G6F4
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human ABCB1.
Immunogen
Recombinant protein corresponding to amino acids 1149-1280 of human ABCB1.
Host
Mouse
Theoretical MW (kDa)
141.1
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Flow Cytometry (1:200-1:400)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: ABCB1-hIgGFc transfected HEK293 cell lysates with ABCB1 monoclonal antibody, clone 4G6F4 (Cat # MAB21392).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with ABCB1 monoclonal antibody, clone 4G6F4 (Cat # MAB21392).Flow Cytometry
Flow cytometric analysis of HL-60 cells with ABCB1 monoclonal antibody, clone 4G6F4 (Cat # MAB21392) (Green). Red: Negative Control. -
Gene Info — ABCB1
Entrez GeneID
5243Protein Accession#
P08183Gene Name
ABCB1
Gene Alias
ABC20, CD243, CLCS, GP170, MDR1, MGC163296, P-GP, PGY1
Gene Description
ATP-binding cassette, sub-family B (MDR/TAP), member 1
Omim ID
171050Gene Ontology
HyperlinkGene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq
Other Designations
ATP-binding cassette, subfamily B, member 1|P glycoprotein 1|P-glycoprotein 1|colchicin sensitivity|doxorubicin resistance|multidrug resistance 1|multidrug resistance protein 1
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