MSH6 monoclonal antibody, clone MSH6/2111
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human MSH6.
Immunogen
Recombinant protein corresponding to amino acid 374-540 of human MSH6.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b, kappa
Recommend Usage
ELISA
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — MSH6
Entrez GeneID
2956Protein Accession#
P52701Gene Name
MSH6
Gene Alias
GTBP, HNPCC5, HSAP
Gene Description
mutS homolog 6 (E. coli)
Omim ID
600678Gene Ontology
HyperlinkGene Summary
This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer. [provided by RefSeq
Other Designations
G/T mismatch-binding protein|mutS homolog 6|sperm-associated protein
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Interactome
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Pathway
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Disease
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