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Last updated: 2017/9/17
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PMS2 monoclonal antibody, clone 349.29.5.2

  • Catalog # : MAB2089
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant PMS2.
  • Immunogen:
  • Recombinant protein corresponding to the first 133 amino acids of human PMS2.
  • Host:
  • Mouse
  • Reactivity:
  • Chimpanzee, Human, Mouse, Rat
  • Specificity:
  • This is an protein A purified antibody directed against PMS2-134 and reacts with full length version of PMS2 in human and hamster tissues. The epitope was putatively mapped to amino acids 58-81 of human PMS2.
  • Form:
  • Liquid
  • Isotype:
  • IgG1, kappa
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.
  • Recommend Usage:
  • ELISA (1:5000-1:20000)
    Western Blot (1:500-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis is shown using PMS2 monoclonal antibody, clone 349.29.5.2 (Cat # MAB2089) to detect human PMS2 protein present in H157 cell lysates.
    Approximately 5, 10 and 30 ug of cell lysate was loaded on a 4-12% NuPage SDS-PAGE gel using MES buffer.
    A single band of ~96 KDa corresponding to the expected molecular weight for human PMS2 protein.
    Personal communication Morphotek Inc.
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 5395
  • Protein Accession#:
  • P54278;NP_000526
  • Gene Name:
  • PMS2
  • Gene Alias:
  • HNPCC4,PMS2CL,PMSL2
  • Gene Description:
  • PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
  • Gene Summary:
  • This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq
  • Other Designations:
  • DNA mismatch repair protein,H_DJ0042M02.9,PMS2 postmeiotic segregation increased 2,mismatch repair endonuclease,postmeiotic segregation increased 2
  • Gene Pathway
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