PMS2 monoclonal antibody, clone AEH-16
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human PMS2.
Immunogen
A synthetic peptide corresponding to human PMS2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Flow Cytometry (1:50)
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Immunohistochemistry (1:50-1:200)
Immunoprecipitation (1:50)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of (1) Jurkat cell lysate, (2)HeLa cell lysate using PMS2 monoclonal antibody, clone AEH-16.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human tonsil using PMS2 monoclonal antibody, clone AEH-16.Immunocytochemistry
Immunofluorescence
Immunoprecipitation
Flow Cytometry
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Gene Info — PMS2
Entrez GeneID
5395Protein Accession#
P54278Gene Name
PMS2
Gene Alias
HNPCC4, PMS2CL, PMSL2
Gene Description
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
Gene Ontology
HyperlinkGene Summary
This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq
Other Designations
DNA mismatch repair protein|H_DJ0042M02.9|PMS2 postmeiotic segregation increased 2|mismatch repair endonuclease|postmeiotic segregation increased 2
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