CCR3 monoclonal antibody, clone ECE-3
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human CCR3.
Immunogen
A synthetic peptide corresponding to human CCR3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunocytochemistry (1:50-200)
Immunofluorescence (1:50-200)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-200)
Western Blot (1:500-2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot (Cell lysate) analysis of K562 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human epidemal cells of skin.Immunocytochemistry
Immunofluorescence
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Gene Info — CCR3
Entrez GeneID
1232Protein Accession#
P51677Gene Name
CCR3
Gene Alias
CC-CKR-3, CD193, CKR3, CMKBR3, MGC102841
Gene Description
chemokine (C-C motif) receptor 3
Omim ID
601268Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq
Other Designations
CC chemokine receptor 3|OTTHUMP00000164718|b-chemokine receptor|eosinophil CC chemokine receptor 3|eosinophil eotaxin receptor
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Interactome
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