CYP26A1 monoclonal antibody, clone F27 P6 A1
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot on recombinant protein corresponding to C-terminal region of CYP26A1 protein using CYP26A1 monoclonal antibody, clone F27 P6 A1 (Cat # MAB1857).
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of CYP26A1.
Immunogen
A synthetic peptide corresponding to C-terminus of human CYP26A1.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot on recombinant protein corresponding to C-terminal region of CYP26A1 protein using CYP26A1 monoclonal antibody, clone F27 P6 A1 (Cat # MAB1857).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CYP26A1
Entrez GeneID
1592Gene Name
CYP26A1
Gene Alias
CP26, CYP26, P450RAI, P450RAI1
Gene Description
cytochrome P450, family 26, subfamily A, polypeptide 1
Omim ID
602239Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq
Other Designations
OTTHUMP00000020102|OTTHUMP00000020103|P450, retinoic acid-inactivating, 1|cytochrome P450, subfamily XXVIA, polypeptide 1|retinoic acid 4-hydroxylase|retinoic acid-metabolizing cytochrome
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Interactome
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Pathway
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Disease
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Publication Reference
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Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
Kumarakulasingham M, Rooney PH, Dundas SR, Telfer C, Melvin WT, Curran S, Murray GI.
Clinical Cancer Research 2005 May; 11(10):3758.
Application：IHC, Human, Human colorectal cancer.
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Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death.
Osanai M, Petkovich M.
Molecular Pharmacology 2005 May; 67(5):1808.
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CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye development.
Sakai Y, Luo T, McCaffery P, Hamada H, Drager UC.
Developmental Biology 2004 Dec; 276(1):143.
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Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
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