MMP14 monoclonal antibody, clone 6A11D1
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More Files
- More Functions
Western Blot
Western Blot analysis of human MMP14 recombinant protein.
Western Blot
Western Blot analysis of (1) HEK293 cells, (2) MMP14-hIgGFc transfected HEK293 cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of bladder cancer tissues with DAB staining.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of ovarian cancer tissues with DAB staining.
Enzyme-linked Immunoabsorbent Assay
ELISA analysis of MMP14 monoclonal antibody.
Flow Cytometry
Flow cytometric analysis of HT1080 cells using MMP14 mouse monoclonal antibody (green) and negative control (red).
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human MMP14.
Immunogen
Recombinant protein corresponding to amino acids 112-246 of of human MMP14 from E. coli.
Host
Mouse
Theoretical MW (kDa)
65.9
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Flow Cytometry (1:200-400)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of human MMP14 recombinant protein.Western Blot
Western Blot analysis of (1) HEK293 cells, (2) MMP14-hIgGFc transfected HEK293 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of bladder cancer tissues with DAB staining.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of ovarian cancer tissues with DAB staining.Enzyme-linked Immunoabsorbent Assay
ELISA analysis of MMP14 monoclonal antibody.Flow Cytometry
Flow cytometric analysis of HT1080 cells using MMP14 mouse monoclonal antibody (green) and negative control (red). -
Gene Info — MMP14
Entrez GeneID
4323Gene Name
MMP14
Gene Alias
MMP-X1, MT1-MMP, MTMMP1
Gene Description
matrix metallopeptidase 14 (membrane-inserted)
Omim ID
600754Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq
Other Designations
matrix metalloproteinase 14|matrix metalloproteinase 14 (membrane-inserted)|membrane type 1 metalloprotease|membrane-type matrix metalloproteinase 1|membrane-type-1 matrix metalloproteinase
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Interactome
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Pathway
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Disease
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