CD68 monoclonal antibody, clone PM-1K
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More Files
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Immunohistochemistry (Frozen sections)
Imunohistochemical analysis of human spleen tissue, using CD68 monoclonal antibody, clone PM-1K (Cat # MAB1715, 10 ug/mL).
Immunohistochemistry
Imunohistochemical analysis of guinea pig small intestine tissue, using CD68 monoclonal antibody, clone PM-1K (Cat # MAB1715, 10 ug/mL).
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Specification
Product Description
Mouse monoclonal antibody raised against native CD68.
Immunogen
Native purified from human peritoneal cells from patients with endometriosis.
Host
Mouse
Reactivity
Guinea pig, Human
Form
Liquid
Isotype
IgG2b, kappa
Recommend Usage
Immunohistochemistry (10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2.0% Block Ace)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Frozen sections)
Imunohistochemical analysis of human spleen tissue, using CD68 monoclonal antibody, clone PM-1K (Cat # MAB1715, 10 ug/mL).Immunohistochemistry
Imunohistochemical analysis of guinea pig small intestine tissue, using CD68 monoclonal antibody, clone PM-1K (Cat # MAB1715, 10 ug/mL). -
Gene Info — CD68
Entrez GeneID
968Gene Name
CD68
Gene Alias
DKFZp686M18236, GP110, SCARD1
Gene Description
CD68 molecule
Omim ID
153634Gene Ontology
HyperlinkGene Summary
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq
Other Designations
CD68 antigen|OTTHUMP00000135285|macrophage antigen CD68|macrosialin|scavenger receptor class D, member 1
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Interactome
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Pathway
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Publication Reference
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Effect of Hypoxia Preconditioning on the Regenerative Capacity of Adipose Tissue Derived Mesenchymal Stem Cells in a Model of Renal Artery Stenosis.
Naba Farooqui, Arjunmohan Mohan, Busra Isik, Busra B Goksu, Roman Thaler, Xiang Yang Zhu, James D Krier, Ishran M Saadiq, Christopher M Ferguson, Kyra L Jordan, Hui Tang, Stephen C Textor, La Tonya J Hickson, Andre J van Wijnen, Alfonso Eirin, Lilach O Lerman, Sandra M Herrmann.
Stem Cells 2022 Oct; sxac073.
Application：IF, Pig, Pig renal.
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Biocompatible Tissue Graft.
Kathleen Anne Dervvin, Anthony Calabro.
United States Patent Application Publication 2016 Mar; [Epub].
Application：IF, Human, Acellular dermis matrix.
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Durable Benefits of Cellular Postconditioning: Long-Term Effects of Allogeneic Cardiosphere-Derived Cells Infused After Reperfusion in Pigs with Acute Myocardial Infarction.
Kanazawa H, Tseliou E, Dawkins JF, De Couto G, Gallet R, Malliaras K, Yee K, Kreke M, Valle I, Smith RR, Middleton RC, Ho CS, Dharmakumar R, Li D, Makkar RR, Fukuda K, Marbán L, Marbán E.
Journal of the American Heart Association 2016 Feb; 5(2):e002796.
Application：IS, Pig, Cardiosphere-derived cells.
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Detection of guinea pig macrophages by a new CD68 monoclonal antibody, PM-1K.
Horikawa T, Komohara Y, Kiyota E, Terasaki Y, Takagi K, Takeya M.
Journal of Molecular Histology 2006 Jan; 37(1-2):15.
Application：IF, IHC-Fr, IHC-P, IP, Human, Mouse, Human spleen, macrophages, Mouse tissues.
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Distribution and cytological properties of macrophages in human Fallopian tubes.
Suenaga Y, Katabuchi H, Fukumatsu Y, Okamura H.
Acta Anatomica 1998 Jul; 163(1):10.
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Role of macrophage tissue factor in the development of the delayed hypersensitivity reaction in monkey skin.
Imamura T, Iyama K, Takeya M, Kambara T, Nakamura S.
Cellular Immunology 1993 Dec; 152(2):614.
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Factor XIII-dependent generation of 5th complement component(C5)-derived monocyte chemotactic factor coinciding with plasma clotting.
Okamoto M, Yamamoto T, Matsubara S, Kukita I, Takeya M, Miyauchi Y, Kambara T.
Biochimica et Biophysica Acta 1992 Jan; 1138(1):53.
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Effect of Hypoxia Preconditioning on the Regenerative Capacity of Adipose Tissue Derived Mesenchymal Stem Cells in a Model of Renal Artery Stenosis.
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