Formalin-fixed and paraffin-embedded human stomach tissue (4 um) stained with MUC1 monoclonal antibody, clone G22-L (Cat # MAB1654) shows strong positive immunostaining of epithelial cells. Kindly performed and provided by Katarina Poliakova, MD and Lubomir Straka, MD, Ph. D., from Clinical Pathology.
This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined. [provided by RefSeq