KRT6 monoclonal antibody, clone SPM269
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Specifications
Product Description
Mouse monoclonal antibody raised against synthetic peptide of human KRT6.
Immunogen
A synthetic peptide corresponding to 11 residues at C-terminus of human KRT6.
Sequence
GSSTIKYTTTS
Host
Mouse
Theoretical MW (kDa)
56
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2a, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.1-0.2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human bladder carcinoma with KRT6 monoclonal antibody, clone SPM269 (Cat # MAB15201).Immunofluorescence
Flow Cytometry
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Gene Info — KRT6A
Entrez GeneID
3853Protein Accession#
P02538;P04259;P48668Gene Name
KRT6A
Gene Alias
CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D
Gene Description
keratin 6A
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq
Other Designations
56 cytoskeletal type II keratin|K6D keratin|cytokeratin 6A|cytokeratin 6C|cytokeratin 6D|keratin 6C|keratin, epidermal type II, K6A|keratin, epidermal type II, K6C|keratin, type II cytoskeletal 6D|type II keratin isoform K6c
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Gene Info — KRT6B
Entrez GeneID
3854Protein Accession#
P02538;P04259;P48668Gene Name
KRT6B
Gene Alias
CK6B, K6B, KRTL1, PC2
Gene Description
keratin 6B
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq
Other Designations
cytokeratin 6B|keratin, epidermal, type II, K6B|keratin, type II cytoskeletal 6B|keratin-like 1 (a type II keratin sequence)
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Gene Info — KRT6C
Entrez GeneID
286887Protein Accession#
P02538;P04259;P48668Gene Name
KRT6C
Gene Alias
K6E, KRT6E, MGC102925, MGC163455, MGC163457
Gene Description
keratin 6C
Gene Ontology
HyperlinkGene Summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq
Other Designations
keratin 6E
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Interactomes
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Publication Reference
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Basal cell-specific and hyperproliferation-related keratins in human breast cancer.
Wetzels RH, Kuijpers HJ, Lane EB, Leigh IM, Troyanovsky SM, Holland R, van Haelst UJ, Ramaekers FC.
The American Journal of Pathology 1991 Mar; 138(3):751.
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Basal cell-specific and hyperproliferation-related keratins in human breast cancer.
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