PTEN monoclonal antibody, clone RM265
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More Files
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Specifications
Product Description
Rabbit recombinant monoclonal antibody raised against human PTEN.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to C-terminus of human PTEN.
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000-1:2000)
Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: HeLa, Lane 2: 293 cell lysates with PTEN monoclonal antibody, clone RM265 (Cat # MAB15139) at a 1:1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human brain with PTEN monoclonal antibody, clone RM265 (Cat # MAB15139) at a 1:1000 dilution.Immunohistochemistry
Immunohistochemical staining of formalin fixed and paraffin embedded human melanoma sections using PTEN monoclonal antibody, clone RM265 (Cat# MAB15139) at a 1:2000 dilution.Immunohistochemistry
Immunohistochemical staining of formalin fixed and paraffin embedded human prostate cancer sections using PTEN monoclonal antibody, clone RM265 (Cat# MAB15139) at a 1:2000 dilution. -
Gene Info — PTEN
Entrez GeneID
5728Protein Accession#
P60484Gene Name
PTEN
Gene Alias
10q23del, BZS, MGC11227, MHAM, MMAC1, PTEN1, TEP1
Gene Description
phosphatase and tensin homolog
Gene Ontology
HyperlinkGene Summary
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq
Other Designations
MMAC1 phosphatase and tensin homolog deleted on chromosome 10|OTTHUMP00000020032|mutated in multiple advanced cancers 1
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Interactomes
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Pathways
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Diseases
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