PTEN recombinant monoclonal antibody, clone PTENS380T382383-E4
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More Files
- More Functions
Western Blot
Western blot analysis of HEK293 cell extract untreated or treated with lambda phosphatase using Phospho-PTEN (Ser380/Thr382/383) antibody PTENS380T382383-E4. Concentration 0.01 ug/mL.
Flow Cytometry
Flow cytometric analysis of A431 cells, untreated and unstained as negative control (blue) or untreated and stained (green) or treated with lambda phosphatase and stained (red) using Phospho-PTEN (S380) antibody, PTENS380-E4 at 0.1 ug/mL.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human PTEN.
Antibody Species
Rabbit
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser380 and Thr382/383 of human phospho PTEN
Reactivity
Human
Form
Liquid
Purification
Protein A+G
Isotype
Rabbit IgG1k
Recommend Usage
Flow Cytometry
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
1X PBS, 0.02% Sodium azide, 50% Glycerol, 0.1% BSA
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of HEK293 cell extract untreated or treated with lambda phosphatase using Phospho-PTEN (Ser380/Thr382/383) antibody PTENS380T382383-E4. Concentration 0.01 ug/mL.Flow Cytometry
Flow cytometric analysis of A431 cells, untreated and unstained as negative control (blue) or untreated and stained (green) or treated with lambda phosphatase and stained (red) using Phospho-PTEN (S380) antibody, PTENS380-E4 at 0.1 ug/mL. -
Gene Info — PTEN
Entrez GeneID
5728Protein Accession#
P60484Gene Name
PTEN
Gene Alias
10q23del, BZS, MGC11227, MHAM, MMAC1, PTEN1, TEP1
Gene Description
phosphatase and tensin homolog
Gene Ontology
HyperlinkGene Summary
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq
Other Designations
MMAC1 phosphatase and tensin homolog deleted on chromosome 10|OTTHUMP00000020032|mutated in multiple advanced cancers 1
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Interactome
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Pathway
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Disease
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