ACACA monoclonal antibody, clone RM232
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of A431 cell lysates with ACACA monoclonal antibody, clone RM232 (Cat # MAB15123) at a 1: 1,000 dilution, showed a band of ACACA (~260 kDa) expressed in A431 cells.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human heart with ACACA monoclonal antibody, clone RM232 (Cat # MAB15123) at 1:300 dilution.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against of human ACACA.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to internal region of human ACACA.
Sequence
N/A
Reactivity
Human
Form
Liquid
Purification
Protein A affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:300-1:500)
Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of A431 cell lysates with ACACA monoclonal antibody, clone RM232 (Cat # MAB15123) at a 1: 1,000 dilution, showed a band of ACACA (~260 kDa) expressed in A431 cells.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human heart with ACACA monoclonal antibody, clone RM232 (Cat # MAB15123) at 1:300 dilution. -
Gene Info — ACACA
Entrez GeneID
31Protein Accession#
Q13085Gene Name
ACACA
Gene Alias
ACAC, ACC, ACC1, ACCA
Gene Description
acetyl-Coenzyme A carboxylase alpha
Omim ID
200350Gene Ontology
HyperlinkGene Summary
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
ACC-alpha|OTTHUMP00000164069|acetyl-CoA carboxylase 1|acetyl-CoA carboxylase-alpha
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Interactome
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Pathway
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Disease
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