CD80 monoclonal antibody, clone C80/1608
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human CD80.
Immunogen
Recombinant protein corresponding to full length human CD80.
Host
Mouse
Theoretical MW (kDa)
60
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Flow Cytometry
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Gene Info — CD80
Entrez GeneID
941Protein Accession#
P33681Gene Name
CD80
Gene Alias
CD28LG, CD28LG1, LAB7
Gene Description
CD80 molecule
Omim ID
112203Gene Ontology
HyperlinkGene Summary
The B-lymphocyte activation antigen B7-1 (formerly referred to as B7) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 (MIM 186760) and CTLA4 (MIM 123890) ligands of T cells.[supplied by OMIM
Other Designations
B-lymphocyte activation antigen B7|CD80 antigen|CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)|costimulatory factor CD80|costimulatory molecule variant IgV-CD80
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Interactome
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Pathway
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Disease
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Publication Reference
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Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28.
Peach RJ, Bajorath J, Naemura J, Leytze G, Greene J, Aruffo A, Linsley PS.
The Journal of Biological Chemistry 1995 Sep; 270(36):21181.
Application:Func, Monkey, COS cells.
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Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4.
Fargeas CA, Truneh A, Reddy M, Hurle M, Sweet R, Sékaly RP.
The Journal of Experimental Medicine 1995 Sep; 182(3):667.
Application:Flow Cyt, Mouse, L cells.
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Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28.
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