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Acidic Cytokeratin monoclonal antibody, clone SPM115

  • Catalog # : MAB12076
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against Acidic Cytokeratin.
  • Immunogen:
  • Solubilized keratin extract from human stratum corneum.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 40-57
  • Reactivity:
  • Human, Mouse, Rabbit, Rat
  • Specificity:
  • This monoclonal antibody recognizes KRT10 (56.5kDa), KRT14 (50kDa), KRT15 (50kDa), KRT16 (48kDa), and KRT19 (40kDa).
  • Form:
  • Liquid
  • Purification:
  • Protein A/G purification
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Immunohistochemistry (0.5-1 ug/mL)
    Western Blot (0.5-1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.05% BSA, 0.05% sodium azide).
  • Storage Instruction:
  • Store at 4°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of VIM in A-431 cell lysate with Acidic Cytokeratin monoclonal antibody, clone SPM115 (Cat# MAB12076).
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin-fixed paraffin-embedded sections) of human skin with Acidic Cytokeratin monoclonal antibody, clone SPM115 (Cat# MAB12076).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 3858
  • Gene Name:
  • KRT10
  • Gene Alias:
  • CK10,K10,KPP
  • Gene Description:
  • keratin 10
  • Gene Summary:
  • This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq
  • Other Designations:
  • cytokeratin 10
  • Gene Information
  • Entrez GeneID:
  • 3861
  • Gene Name:
  • KRT14
  • Gene Alias:
  • CK14,EBS3,EBS4,K14,NFJ
  • Gene Description:
  • keratin 14
  • Gene Summary:
  • This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq
  • Other Designations:
  • cytokeratin 14,keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)
  • Gene Information
  • Entrez GeneID:
  • 3866
  • Gene Name:
  • KRT15
  • Gene Alias:
  • CK15,K15,K1CO
  • Gene Description:
  • keratin 15
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000165060,cytokeratin 15,keratin-15, basic,keratin-15, beta,type I cytoskeletal 15
  • Gene Information
  • Entrez GeneID:
  • 3868
  • Gene Name:
  • KRT16
  • Gene Alias:
  • CK16,K16,K1CP,KRT16A,NEPPK
  • Gene Description:
  • keratin 16
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq
  • Other Designations:
  • cytokeratin 16,focal non-epidermolytic palmoplantar keratoderma,keratin, type I cytoskeletal 16
  • Gene Information
  • Entrez GeneID:
  • 3880
  • Gene Name:
  • KRT19
  • Gene Alias:
  • CK19,K19,K1CS,MGC15366
  • Gene Description:
  • keratin 19
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq
  • Other Designations:
  • 40-kDa keratin intermediate filament,cytokeratin 19,keratin, type I cytoskeletal 19,keratin, type I, 40-kd
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