BCL2L1 monoclonal antibody, clone SPM165
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Specifications
Product Description
Mouse monoclonal antibody raised against synthetic peptide of BCL2L1.
Immunogen
A synthetic peptide corresponding to amino acids 33-50 of mouse BCL2L1.
Sequence
NRTEAPEGTESEMETPSA
Host
Mouse
Theoretical MW (kDa)
27
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2a
Recommend Usage
Immunohistochemistry (0.5-1 ug/mL)
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of BCL2L1 in Jurkat cell lysate using BCL2L1 monoclonal antibody, clone SPM165 (Cat # MAB12023).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of Hodgkin's lymphoma with BCL2L1 monoclonal antibody, clone SPM165 (Cat # MAB12023). -
Gene Info — BCL2L1
Entrez GeneID
598Gene Name
BCL2L1
Gene Alias
BCL-XL/S, BCL2L, BCLX, Bcl-X, DKFZp781P2092, bcl-xL, bcl-xS
Gene Description
BCL2-like 1
Omim ID
600039Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq
Other Designations
OTTHUMP00000030550|OTTHUMP00000030551|OTTHUMP00000030553
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Interactomes
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Pathways
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Diseases
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