CENPB (Human) ELISA Kit is a competitive enzyme-linked immunosorbent assay for quantitative measurement of human CENPB in cell culture and cell lysate.
Calibration Range:
0.625 to 40 ng/mL
Reactivity:
Human
Quality Control Testing:
Standard curve
The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Storage Instruction:
Store components of the kit at 4°C or -20°C as described in the protocol.
This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq
Other Designations:
OTTHUMP00000030132,centromere autoantigen B,centromere protein B,centromere protein B (80kD)