CENPB (Human) IP-WB Antibody Pair
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Specification
Product Description
This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
Reactivity
Human
Interspecies Antigen Sequence
Mouse (91%)
Quality Control Testing
Immunoprecipitation-Western Blot (IP-WB)
Immunoprecipitation of CENPB transfected lysate using rabbit polyclonal anti-CENPB and Protein A Magnetic Bead (U0007), and immunoblotted with mouse purified polyclonal anti-CENPB.
Supplied Product
Antibody pair set content:
1. Antibody pair for IP: rabbit polyclonal anti-CENPB (300 ul)
2. Antibody pair for WB: mouse purified polyclonal anti-CENPB (50 ug)
Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
Immunoprecipitation-Western Blot
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Gene Info — CENPB
Entrez GeneID
1059Gene Name
CENPB
Gene Alias
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Gene Description
centromere protein B, 80kDa
Omim ID
117140Gene Ontology
HyperlinkGene Summary
This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq
Other Designations
OTTHUMP00000030132|centromere autoantigen B|centromere protein B|centromere protein B (80kD)
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