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Last updated: 2017/1/15
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UPF3A purified MaxPab mouse polyclonal antibody (B01P)MaxPab

  • Catalog # : H00065110-B01P
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  • Specification
  • Product Description:
  • Mouse polyclonal antibody raised against a full-length human UPF3A protein.
  • Immunogen:
  • UPF3A (NP_542418.1, 1 a.a. ~ 443 a.a) full-length human protein.
  • Sequence:
  • MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPREEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRNPDDILLFRDRFDGYIFLDSKDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPEKREEAE
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Antibody reactive against mammalian transfected lysate.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western Blot analysis of UPF3A expression in transfected 293T cell line (H00065110-T01) by UPF3A MaxPab polyclonal antibody.

    Lane 1: UPF3A transfected lysate(48.73 KDa).
    Lane 2: Non-transfected lysate.
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  • Application Image
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
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  • Gene Information
  • Gene Name:
  • UPF3A
  • Gene Alias:
  • HUPF3A,RENT3A,UPF3
  • Gene Description:
  • UPF3 regulator of nonsense transcripts homolog A (yeast)
  • Gene Summary:
  • This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000018789,UPF3 regulator of nonsense transcripts homolog A
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