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UPF3A 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00065110-T01
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-UPF3A full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 48.84
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-UPF3A antibody (H00065110-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00065110-T01
    UPF3A transfected lysate.
    Western Blot
    QC Testing of H00065110-T01
    Lane 1: UPF3A transfected lysate ( 48.84 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Gene Name:
  • UPF3A
  • Gene Alias:
  • HUPF3A,RENT3A,UPF3
  • Gene Description:
  • UPF3 regulator of nonsense transcripts homolog A (yeast)
  • Gene Summary:
  • This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000018789,UPF3 regulator of nonsense transcripts homolog A
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