PTBP2 polyclonal antibody (A01)
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length recombinant PTBP2.
Immunogen
PTBP2 (AAH16582, 1 a.a. ~ 532 a.a) full-length recombinant protein with GST tag.
Sequence
MDGIVTEVAVGVKRGSDELLSGSVLSSPNSNMSSMVVTANGNDSKKFKGEDKMDGAPSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKTDNTLNQRAQAVLQAVTAVQTANTPLSGTTVSESAVTPAQSPVLRIIIDNMYYPVTLDVLHQIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTRPDLPSGDGQPALDPAIAAAFAKETSLLAVPGALSPLAIPNAAAAAAAAAAGRVGMPGVSAGGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTVQLPREGLDDQGLTKDFGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQRDHKMALLQMATVEEAIQALIDLHNYNLGENHHLRVSFSKSTI
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (99); Rat (99)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (84.63 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — PTBP2
Entrez GeneID
58155GeneBank Accession#
BC016582Protein Accession#
AAH16582Gene Name
PTBP2
Gene Alias
FLJ34897, PTB, PTBLP, brPTB, nPTB, nPTB5, nPTB6, nPTB7, nPTB8
Gene Description
polypyrimidine tract binding protein 2
Omim ID
608449Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein but it is expressed primarily in the brain. [provided by RefSeq
Other Designations
OTTHUMP00000012411|PTB-like|neural polypyrimidine tract binding protein|splicing regulator
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Interactome
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Disease
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Publication Reference
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Matrin3 binds directly to intronic pyrimidine-rich sequences and controls alternative splicing.
Uemura Y, Oshima T, Yamamoto M, Reyes CJ, Costa Cruz PH, Shibuya T, Kawahara Y.
Genes to Cells : Devoted to Molecular & Cellular Mechanisms 2017 Jul; 22(9):785.
Application:WB-Tr, Human, SH-SY5Y cells.
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PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus.
Shibasaki T, Tokunaga A, Sakamoto R, Sagara H, Noguchi S, Sasaoka T, Yoshida N.
Cerebral Cortex (New York, N.Y. : 1991) 2013 Aug; 23(8):1824.
Application:WB-Ti, IHC-P, Mouse, Brains of pups and embryos.
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PTBP1 Is Required for Embryonic Development before Gastrulation.
Suckale J, Wendling O, Masjkur J, Jager M, Munster C, Anastassiadis K, Stewart AF, Solimena M.
PLoS One 2011 Feb; 6(2):e16992.
Application:IHC, Mouse, Decidua.
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Polypyrimidine tract-binding protein 1 regulates the alternative splicing of dopamine receptor D2.
Sasabe T, Futai E, Ishiura S.
Journal of Neurochemistry 2011 Jan; 116(1):76.
Application:WB, Human, HEK 293 cells.
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Polypyrimidine Tract-Binding Protein 2 Binds to Selective, Intronic Messenger RNA and MicroRNA Targets in the Mouse Testis.
Xu M, Hecht NB.
Biology of Reproduction 2011 Mar; 84(3):435.
Application:WB-Tr, Mouse, N2A cells.
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Alternative splicing of neurexins: a role for neuronal polypyrimidine tract binding protein.
Resnick M, Segall A, G GR, Lupowitz Z, Zisapel N.
Neuroscience Letters 2008 May; 439(3):235.
Application:WB-Tr, Mouse, RGC-5 cells.
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Two-dimensional fluorescence difference gel electrophoresis analysis of spermatogenesis in the rat.
Rolland AD, Evrard B, Guitton N, Lavigne R, Calvel P, Couvet M, Jegou B, Pineau C.
Journal of Proteome Research 2006 Dec; 6(2):683.
Application:WB, Rat, Rat spermatogonia (SPG), pachytene spermatocytes (SPC), and early spermatids (SPT).
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Matrin3 binds directly to intronic pyrimidine-rich sequences and controls alternative splicing.
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