Products

Western Blot (Transfected lysate)

Western Blot analysis of PCDHGC5 expression in transfected 293T cell line by PCDHGC5 monoclonal antibody (M08), clone 3A6.

Lane 1: PCDHGC5 transfected lysate (Predicted MW: 95.2 KDa).
Lane 2: Non-transfected lysate.

Western Blot (Recombinant protein)

Sandwich ELISA (Recombinant protein)

Detection limit for recombinant GST tagged PCDHGC5 is 0.1 ng/ml as a capture antibody.

ELISA

Entrez GeneID

56097

GeneBank Accession#

NM_018929

Protein Accession#

NP_061752

Gene Name

PCDHGC5

Gene Alias

MGC138286, MGC138288, PCDH-GAMMA-C5

Gene Description

protocadherin gamma subfamily C, 5

Omim ID

606306

Gene Ontology

Hyperlink

Gene Summary

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq

Other Designations

OTTHUMP00000160024