DPH5 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human DPH5 protein.
Immunogen
DPH5 (NP_001070862.1, 1 a.a. ~ 285 a.a) full-length human protein.
Sequence
MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREEVEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCCGLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (91); Rat (91)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of DPH5 expression in transfected 293T cell line (H00051611-T01) by DPH5 MaxPab polyclonal antibody.
Lane 1: DPH5 transfected lysate(31.35 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — DPH5
Entrez GeneID
51611GeneBank Accession#
BC053857.1Protein Accession#
NP_001070862.1Gene Name
DPH5
Gene Alias
AD-018, CGI-30, HSPC143, MGC61450, NPD015
Gene Description
DPH5 homolog (S. cerevisiae)
Omim ID
611075Gene Ontology
HyperlinkGene Summary
This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000012522|OTTHUMP00000012523|OTTHUMP00000012524|diphthamide biosynthesis methyltransferase|diphthine synthase|protein x 0011
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