Immunoprecipitation of PARD6A transfected lysate using anti-PARD6A MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with PARD6A purified MaxPab mouse polyclonal antibody (B01P) (H00050855-B01P).
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Tax-interacting protein 40,par-6 partitioning defective 6 homolog alpha,partitioning defective-6 homolog alpha,partitioning-defective protein 6