PARD6A polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
PARD6A polyclonal antibody (Cat # PAB6553) (10 ug/mL) staining of paraffin embedded human pancreas. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PARD6A.
Immunogen
A synthetic peptide corresponding to human PARD6A.
Sequence
C-GSRIRGDGSGFSL
Host
Goat
Theoretical MW (kDa)
37.4, 37.3
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Immunohistochemistry (10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
PARD6A polyclonal antibody (Cat # PAB6553) (10 ug/mL) staining of paraffin embedded human pancreas. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PARD6A
Entrez GeneID
50855Protein Accession#
NP_058644Gene Name
PARD6A
Gene Alias
PAR-6A, PAR6, PAR6C, PAR6alpha, TAX40, TIP-40
Gene Description
par-6 partitioning defective 6 homolog alpha (C. elegans)
Omim ID
607484Gene Ontology
HyperlinkGene Summary
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
Tax-interacting protein 40|par-6 partitioning defective 6 homolog alpha|partitioning defective-6 homolog alpha|partitioning-defective protein 6
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Interactome
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Pathway
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Disease
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Publication Reference
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The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1.
Johansson A, Driessens M, Aspenstrom P.
Journal of Cell Science 2000 Sep; 113 ( Pt 18):3267.
Application：IF, IHC, Dog, MDCK cells.
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The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1.
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