GREM1 (Human) Recombinant Protein (Q02)
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More Files
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Specifications
Product Description
Human GREM1 partial ORF ( NP_037504.1, 25 a.a. - 124 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
KKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNS
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.63
Interspecies Antigen Sequence
Mouse (97); Rat (98)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — GREM1
Entrez GeneID
26585GeneBank Accession#
NM_013372Protein Accession#
NP_037504.1Gene Name
GREM1
Gene Alias
CKTSF1B1, DAND2, DRM, GREMLIN, IHG-2, MGC126660, PIG2
Gene Description
gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
Omim ID
603054Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. [provided by RefSeq
Other Designations
cysteine knot superfamily 1, BMP antagonist 1|down-regulated in Mos-transformed cells|gremlin 1-like protein|gremlin-1|increased in high glucose-2|proliferation-inducing gene 2
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Interactomes
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Diseases
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