BACE1 purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of BACE1 expression in transfected 293T cell line (H00023621-T01) by BACE1 MaxPab polyclonal antibody.
Lane 1: BACE1 transfected lysate(52.90 KDa).
Lane 2: Non-transfected lysate.
In situ Proximity Ligation Assay (Cell)
Proximity Ligation Analysis of protein-protein interactions between BACE1 and CSNK1D. HeLa cells were stained with anti-BACE1 rabbit purified polyclonal 1:1200 and anti-CSNK1D mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human BACE1 protein.
Immunogen
BACE1 (NP_620428.1, 1 a.a. ~ 476 a.a) full-length human protein.
Sequence
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (96); Rat (96)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of BACE1 expression in transfected 293T cell line (H00023621-T01) by BACE1 MaxPab polyclonal antibody.
Lane 1: BACE1 transfected lysate(52.90 KDa).
Lane 2: Non-transfected lysate.
In situ Proximity Ligation Assay (Cell)
Proximity Ligation Analysis of protein-protein interactions between BACE1 and CSNK1D. HeLa cells were stained with anti-BACE1 rabbit purified polyclonal 1:1200 and anti-CSNK1D mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue). -
Gene Info — BACE1
Entrez GeneID
23621GeneBank Accession#
NM_138972Protein Accession#
NP_620428.1Gene Name
BACE1
Gene Alias
ASP2, BACE, FLJ90568, HSPC104, KIAA1149
Gene Description
beta-site APP-cleaving enzyme 1
Omim ID
604252Gene Ontology
HyperlinkGene Summary
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
APP beta-secretase|aspartyl protease 2|beta-secretase|beta-site amyloid beta A4 precursor protein-cleaving enzyme|beta-site amyloid precursor protein cleaving enzyme|memapsin-2|membrane-associated aspartic protease 2|transmembrane aspartic proteinase Asp2
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Interactome
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Disease
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