TREX1 purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
TREX1 MaxPab rabbit polyclonal antibody. Western Blot analysis of TREX1 expression in human pancreas.
Western Blot (Cell lysate)
TREX1 MaxPab rabbit polyclonal antibody. Western Blot analysis of TREX1 expression in K-562.
Western Blot (Cell lysate)
TREX1 MaxPab rabbit polyclonal antibody. Western Blot analysis of TREX1 expression in HeLa.
Western Blot (Cell lysate)
TREX1 MaxPab rabbit polyclonal antibody. Western Blot analysis of TREX1 expression in Raw 264.7.
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human TREX1 protein.
Immunogen
TREX1 (NP_057465.1, 1 a.a. ~ 369 a.a) full-length human protein.
Sequence
MGPGARRQGRIVQGRPEMCFCPPPTPLPPLRILTLGTHTPTPCSSPGSAAGTYPTMGSQALPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASARTKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLAVATLYGLSLATPGE
Host
Rabbit
Reactivity
Human, Mouse
Interspecies Antigen Sequence
Mouse (73); Rat (74)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
TREX1 MaxPab rabbit polyclonal antibody. Western Blot analysis of TREX1 expression in human pancreas.Western Blot (Cell lysate)
TREX1 MaxPab rabbit polyclonal antibody. Western Blot analysis of TREX1 expression in K-562.Western Blot (Cell lysate)
TREX1 MaxPab rabbit polyclonal antibody. Western Blot analysis of TREX1 expression in HeLa.Western Blot (Cell lysate)
TREX1 MaxPab rabbit polyclonal antibody. Western Blot analysis of TREX1 expression in Raw 264.7. -
Gene Info — TREX1
Entrez GeneID
11277GeneBank Accession#
NM_016381Protein Accession#
NP_057465.1Gene Name
TREX1
Gene Alias
AGS1, AGS5, CRV, DKFZp434J0310, DRN3, HERNS
Gene Description
three prime repair exonuclease 1
Gene Ontology
HyperlinkGene Summary
This gene encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
3' repair exonuclease 1|OTTHUMP00000164813|deoxyribonuclease III, dnaQ/mutD-like
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Interactome
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Disease
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Publication Reference
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Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs.
Tomicic MT, Aasland D, Nikolova T, Kaina B, Christmann M.
Biochimica et Biophysica Acta 2013 Aug; 1833(8):1832.
Application：IF, WB-Ce, WB-Tr, Human, VH10tert fibroblasts, LN229, D03, GM637 cells.
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Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage.
Christmann M, Tomicic MT, Aasland D, Berdelle N, Kaina B.
Nucleic Acids Research 2010 Oct; 38(19):6418.
Application：IP, WB, Mouse, MEFs.
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Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs.
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