RIPK3 (Human) Recombinant Protein (P01)
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More Files
- More Functions
Kinase Assay
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Specification
Product Description
Human RIPK3 full-length ORF ( AAH62584, 1 a.a. - 518 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
82.72
Interspecies Antigen Sequence
Mouse (59); Rat (60)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Kinase Assay
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — RIPK3
Entrez GeneID
11035GeneBank Accession#
BC062584Protein Accession#
AAH62584Gene Name
RIPK3
Gene Alias
RIP3
Gene Description
receptor-interacting serine-threonine kinase 3
Omim ID
605817Gene Ontology
HyperlinkGene Summary
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq
Other Designations
RIP-like protein kinase 3|receptor interacting protein 3
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Interactome
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Disease
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Publication Reference
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The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome.
Lee SB, Kim JJ, Han SA, Fan Y, Guo LS, Aziz K, Nowsheen S, Kim SS, Park SY, Luo Q, Chung JO, Choi SI, Aziz A, Yin P, Tong SY, Fiesel FC, Springer W, Zhang JS, Lou Z.
Nature Cell Biology 2019 Aug; 21(8):940.
Application：Func, WB-Re, Recombinant proteins.
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Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI.
Northington FJ, Chavez-Valdez R, Graham EM, Razdan S, Gauda EB, Martin LJ.
Journal of Cerebral Blood Flow and Metabolism 2011 Jan; 31(1):178.
Application：WB-Re, Recombinant protein.
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The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome.
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