CPSF4 purified MaxPab mouse polyclonal antibody (B02P)
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More Files
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Specifications
Product Description
Mouse polyclonal antibody raised against a full-length human CPSF4 protein.
Immunogen
CPSF4 (AAH50738.1, 1 a.a. ~ 243 a.a) full-length human protein.
Sequence
MQEIIASVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEFFLKAACGKGGMCPFRHISGEKTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYDRGFCKHGPLCRHRHTRRVICVNYLVGFCPEGPSCKFMHPRFELPMGTTEQPPLPQQTQPPAKRTPQVIGVMQSQNSSAGNRGPRPLEQVTCYKCGEKGHYANRCTKGHLAFLSGQ
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (85); Rat (98)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of CPSF4 expression in transfected 293T cell line (H00010898-T03) by CPSF4 MaxPab polyclonal antibody.
Lane 1: CPSF4 transfected lysate(26.73 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — CPSF4
Entrez GeneID
10898GeneBank Accession#
BC050738Protein Accession#
AAH50738.1Gene Name
CPSF4
Gene Alias
CPSF30, NAR, NEB1
Gene Description
cleavage and polyadenylation specific factor 4, 30kDa
Omim ID
603052Gene Ontology
HyperlinkGene Summary
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq
Other Designations
cleavage-polyadenylation specificity factor, 30kD|no arches-like zinc finger protein
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