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CPSF4 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00010898-T03
  • Visit Frequency :
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-CPSF4 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 27.4
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-CPSF4 antibody (H00010898-B02P) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00010898-T03
    CPSF4 transfected lysate.
    Western Blot
    QC Testing of H00010898-T03
    Lane 1: CPSF4 transfected lysate ( 27.40 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Gene Name:
  • CPSF4
  • Gene Alias:
  • CPSF30,NAR,NEB1
  • Gene Description:
  • cleavage and polyadenylation specific factor 4, 30kDa
  • Gene Summary:
  • Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq
  • Other Designations:
  • cleavage-polyadenylation specificity factor, 30kD,no arches-like zinc finger protein
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