MTHFD2 DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a partial-length human MTHFD2 DNA using DNAx™ Immune technology.
Technology
Immunogen
Extracellular membrane domain (ECD) human DNA
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — MTHFD2
Entrez GeneID
10797GeneBank Accession#
BC001548Protein Accession#
AAH01548Gene Name
MTHFD2
Gene Alias
NMDMC
Gene Description
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Omim ID
604887Gene Ontology
HyperlinkGene Summary
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq
Other Designations
NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase|methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase|methylene tetrahydrofolate dehydrogenase 2
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Interactome
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Pathway
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Disease
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