Products

Immunoprecipitation-Western Blot

Entrez GeneID

Gene Name

TAF6L

Gene Alias

FLJ11136, MGC4288, PAF65A

Gene Description

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa

Omim ID

Gene Ontology

Gene Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq

Other Designations

TAF6-like RNA polymerase II|TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65 kD|p300/CBP-associated factor (PCAF)-associated factor 65