NDRG1 monoclonal antibody (M03), clone 2D7
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More Files
- More Functions
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant NDRG1.
Immunogen
NDRG1 (AAH03175, 1 a.a. ~ 394 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGNSAGPKSMEVSC
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (93); Rat (93)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (69.08 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to NDRG1 on formalin-fixed paraffin-embedded human endometrium. [antibody concentration 0.7 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged NDRG1 is approximately 1ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to NDRG1 on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — NDRG1
Entrez GeneID
10397GeneBank Accession#
BC003175Protein Accession#
AAH03175Gene Name
NDRG1
Gene Alias
CAP43, CMT4D, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5
Gene Description
N-myc downstream regulated 1
Gene Ontology
HyperlinkGene Summary
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. It is necessary for p53-mediated caspase activation and apoptosis. Mutation in this gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations
differentiation-related gene 1 protein|nickel-specific induction protein Cap43|protein regulated by oxygen-1|reducing agents and tunicamycin-responsive protein|tunicamycin-responsive protein
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Interactome
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Disease
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Publication Reference
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MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner.
Kato W, Nishio M, To Y, Togashi H, Mak TW, Takada H, Ohga S, Maehama T, Suzuki A.
Genes to Cells : Devoted to Molecular & Cellular Mechanisms 2019 Jul; 24(7):485.
Application:WB, Mouse, Mouse thymocyte.
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The prognostic value of decreased NDRG1 expression in patients with digestive system cancers: A meta-analysis.
Chen K, Liu XH, Wang FR, Liu HP, Huang ZP, Chen X.
Medicine 2018 Oct; 97(41):e12455.
Application:IHC, Human, Human gastric cancer.
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A novel molecular marker for early detection and evaluating prognosis of gastric cancer: N-myc downstream regulated gene-1 (NDRG1).
Jiang K, Shen Z, Ye Y, Yang X, Wang S.
Scandinavian Journal of Gastroenterology 2010 Aug; 45(7-8):898.
Application:IHC-P, Human, Human gastric cancer.
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Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry.
Leth-Larsen R, Lund R, Hansen HV, Laenkholm AV, Tarin D, Jensen ON, Ditzel HJ.
Molecular & Cellular Proteomics 2009 Jun; 8(6):1436.
Application:ICC, Human, M-4A4, MDA-MB-435, NM-2C5 cells.
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MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner.
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