BCL2L10 polyclonal antibody (A01)
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant BCL2L10.
Immunogen
BCL2L10 (NP_065129, 1 a.a. ~ 92 a.a) partial recombinant protein with GST tag.
Sequence
MVDQLRERTTMADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGP
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (48); Rat (46)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — BCL2L10
Entrez GeneID
10017GeneBank Accession#
NM_020396Protein Accession#
NP_065129Gene Name
BCL2L10
Gene Alias
BCL-B, Boo, Diva, MGC129810, MGC129811
Gene Description
BCL2-like 10 (apoptosis facilitator)
Omim ID
606910Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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Subcellular dynamics of the maternal cell death regulator BCL2L10 in human preimplantation embryos.
Guerin JF, Cornut-Thibaut A, Giscard-Destaing S, Pouvreau S, Guillemin Y, Aouacheria A.
Human Reproduction 2013 Jan; 28(3):729.
Application：IF, Human, Embryos.
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Oocytes and early embryos selectively express the survival factor BCL2L10.
Guillemin Y, Lalle P, Gillet G, Guerin JF, Hamamah S, Aouacheria A.
Journal of Molecular Medicine 2009 Sep; 87(9):923.
Application：IF, WB, Human, Mouse, Oocytes.
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Subcellular dynamics of the maternal cell death regulator BCL2L10 in human preimplantation embryos.
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