BCL2L10 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of BCL2L10 in Jurkat lysate with BCL2L10 polyclonal antibody (Cat # PAB12902) at 1 ug/mL in the (A) absence and (B) presence of blocking peptide.
Immunocytochemistry
Immunocytochemistry of BCL2L10 in Jurkat cells with BCL2L10 polyclonal antibody (Cat # PAB12902) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BCL2L10.
Immunogen
A synthetic peptide corresponding to amino acids near N-terminus of human BCL2L10.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of BCL2L10 in Jurkat lysate with BCL2L10 polyclonal antibody (Cat # PAB12902) at 1 ug/mL in the (A) absence and (B) presence of blocking peptide.Immunocytochemistry
Immunocytochemistry of BCL2L10 in Jurkat cells with BCL2L10 polyclonal antibody (Cat # PAB12902) at 10 ug/mL . -
Gene Info — BCL2L10
Entrez GeneID
10017Protein Accession#
NP_065129Gene Name
BCL2L10
Gene Alias
BCL-B, Boo, Diva, MGC129810, MGC129811
Gene Description
BCL2-like 10 (apoptosis facilitator)
Omim ID
606910Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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The Bcl-2 protein family and its role in the development of neoplastic disease.
Heiser D, Labi V, Erlacher M, Villunger A.
Experimental Gerontology 2004 Aug; 39(8):1125.
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The Bcl-2 family: roles in cell survival and oncogenesis.
Cory S, Huang DC, Adams JM.
Oncogene 2003 Nov; 22(53):8590.
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Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak.
Ke N, Godzik A, Reed JC.
The Journal of Biological Chemistry 2001 Apr; 276(16):12481.
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The Bcl-2 protein family and its role in the development of neoplastic disease.
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