ADAMTS4 monoclonal antibody (M01), clone 2A6
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More Files
- More Functions
Immunoprecipitation
Immunoprecipitation of ADAMTS4 transfected lysate using anti-ADAMTS4 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with ADAMTS4 MaxPab rabbit polyclonal antibody.
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged ADAMTS4 is 0.3 ng/ml as a capture antibody.
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant ADAMTS4.
Immunogen
ADAMTS4 (AAH63293, 693 a.a. ~ 802 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
RKFRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFV
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Rat (84)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Immunoprecipitation
Immunoprecipitation of ADAMTS4 transfected lysate using anti-ADAMTS4 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with ADAMTS4 MaxPab rabbit polyclonal antibody.Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged ADAMTS4 is 0.3 ng/ml as a capture antibody.ELISA
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Gene Info — ADAMTS4
Entrez GeneID
9507GeneBank Accession#
BC063293Protein Accession#
AAH63293Gene Name
ADAMTS4
Gene Alias
ADAMTS-2, ADAMTS-4, ADMP-1, KIAA0688
Gene Description
ADAM metallopeptidase with thrombospondin type 1 motif, 4
Omim ID
603876Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq
Other Designations
OTTHUMP00000032249|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4|aggrecanase-1
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Interactome
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Disease
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