ADAMTS4 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of human fetal brain lysate with ADAMTS4 polyclonal antibody (Cat # PAB18812) at 1 : 1000 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed paraffin-embedded human brain tissue with ADAMTS4 polyclonal antibody (Cat # PAB18812) at 1 : 200 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ADAMTS4.
Immunogen
A synthetic peptide corresponding to amino acids at C-terminus of human ADAMTS4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
ELISA (1:160000)
Western Blot (1:200-1:500)
Immunohistochemistry (1:100-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.02% sodium azide
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of human fetal brain lysate with ADAMTS4 polyclonal antibody (Cat # PAB18812) at 1 : 1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed paraffin-embedded human brain tissue with ADAMTS4 polyclonal antibody (Cat # PAB18812) at 1 : 200 dilution.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ADAMTS4
Entrez GeneID
9507Gene Name
ADAMTS4
Gene Alias
ADAMTS-2, ADAMTS-4, ADMP-1, KIAA0688
Gene Description
ADAM metallopeptidase with thrombospondin type 1 motif, 4
Omim ID
603876Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq
Other Designations
OTTHUMP00000032249|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4|aggrecanase-1
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Interactome
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Disease
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