Pancreatic cancers require autophagy for tumor growth. Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC.Genes Dev. 2011 Apr 1;25(7):717-29. Epub 2011 Mar 15.
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq
EBI3-associated protein p60,Paget disease of bone 3,oxidative stress induced like,phosphotyrosine independent ligand for the Lck SH2 domain p62,ubiquitin-binding protein p62