PDE5A polyclonal antibody (A01)
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant PDE5A.
Immunogen
PDE5A (NP_001074, 29 a.a. ~ 138 a.a) partial recombinant protein with GST tag.
Sequence
SVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSVPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTP
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (88); Rat (86)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
ELISA
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Gene Info — PDE5A
Entrez GeneID
8654GeneBank Accession#
NM_001083Protein Accession#
NP_001074Gene Name
PDE5A
Gene Alias
CGB-PDE, CN5A, PDE5, PDE5A1
Gene Description
phosphodiesterase 5A, cGMP-specific
Omim ID
603310Gene Ontology
HyperlinkGene Summary
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase|phosphodiesterase 5A
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Interactome
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Pathway
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Disease
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Publication Reference
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Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model.
Meyer C, Sevko A, Ramacher M, Bazhin AV, Falk CS, Osen W, Borrello I, Kato M, Schadendorf D, Baniyash M, Umansky V.
PNAS 2011 Oct; 108(41):17111.
Application：WB, Mouse, Mouse myeloid-derived suppressor cells.
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Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model.
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