SOCS1 purified MaxPab mouse polyclonal antibody (B01P)
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human SOCS1 protein.
Immunogen
SOCS1 (AAI53089.1, 1 a.a. ~ 211 a.a) full-length human protein.
Sequence
MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (95)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of SOCS1 expression in transfected 293T cell line (H00008651-T01) by SOCS1 MaxPab polyclonal antibody.
Lane 1: SOCS1 transfected lysate(23.21 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — SOCS1
Entrez GeneID
8651GeneBank Accession#
BC153088.1Protein Accession#
AAI53089.1Gene Name
SOCS1
Gene Alias
CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Gene Description
suppressor of cytokine signaling 1
Omim ID
603597Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq
Other Designations
JAK binding protein|STAT induced SH3 protein 1|Tec-interacting protein 3|cytokine-inducible SH2 protein 1
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