CDC45L monoclonal antibody (M02), clone 4C2
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant CDC45L.
Immunogen
CDC45L (NP_003495, 477 a.a. ~ 566 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
FVCSTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDLSVIELKAEDRSKFLDALISLLS
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (93); Rat (96)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (35.64 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
CDC45L monoclonal antibody (M02), clone 4C2 Western Blot analysis of CDC45L expression in Jurkat ( Cat # L017V1 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CDC45L is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — CDC45L
Entrez GeneID
8318GeneBank Accession#
NM_003504Protein Accession#
NP_003495Gene Name
CDC45L
Gene Alias
CDC45, CDC45L2, PORC-PI-1
Gene Description
CDC45 cell division cycle 45-like (S. cerevisiae)
Omim ID
603465Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported. [provided by RefSeq
Other Designations
CDC45 (cell division cycle 45, S.cerevisiae, homolog)-like|CDC45-like|CDC45-related protein|cell division cycle 45-like 2|human CDC45
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Interactome
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Pathway
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Disease
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