CDC45L rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human CDC45L peptide using ARM Technology.
Immunogen
A synthetic peptide of human CDC45L is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human CDC45L peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — CDC45L
Entrez GeneID
8318GeneBank Accession#
CDC45LGene Name
CDC45L
Gene Alias
CDC45, CDC45L2, PORC-PI-1
Gene Description
CDC45 cell division cycle 45-like (S. cerevisiae)
Omim ID
603465Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported. [provided by RefSeq
Other Designations
CDC45 (cell division cycle 45, S.cerevisiae, homolog)-like|CDC45-like|CDC45-related protein|cell division cycle 45-like 2|human CDC45
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