SCD monoclonal antibody (M02), clone 1B7
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Specifications
Product Description
Mouse monoclonal antibody raised against a partial recombinant SCD.
Immunogen
SCD (NP_005054.3, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYT
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (71); Rat (64)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
SCD monoclonal antibody (M02), clone 1B7. Western Blot analysis of SCD expression in MCF-7.Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged SCD is 0.03 ng/ml as a capture antibody.ELISA
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Gene Info — SCD
Entrez GeneID
6319GeneBank Accession#
NM_005063.4Protein Accession#
NP_005054.3Gene Name
SCD
Gene Alias
FADS5, MSTP008, SCD1
Gene Description
stearoyl-CoA desaturase (delta-9-desaturase)
Omim ID
604031Gene Ontology
HyperlinkGene Summary
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an iron-containing enzyme that catalyzes a rate-limiting step in the synthesis of unsaturated fatty acids. The principal product of SCD is oleic acid, which is formed by desaturation of stearic acid. The ratio of stearic acid to oleic acid has been implicated in the regulation of cell growth and differentiation through effects on cell membrane fluidity and signal transduction. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 and SCD5 (MIM 608370), have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Zhang et al. (1999) [PubMed 10229681]; Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM
Other Designations
OTTHUMP00000020279|acyl-CoA desaturase|delta-9-desaturase|fatty acid desaturase|predicted protein of HQ0998|stearoyl-CoA desaturase
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Interactomes
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Pathways
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Diseases
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