RGS2 monoclonal antibody (M01), clone 4C4
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Specifications
Product Description
Mouse monoclonal antibody raised against a partial recombinant RGS2.
Immunogen
RGS2 (AAH07049, 111 a.a. ~ 211 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
EFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
RGS2 monoclonal antibody (M01), clone 4C4 Western Blot analysis of RGS2 expression in MCF-7 ( Cat # L046V1 ).Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to RGS2 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged RGS2 is approximately 0.1ng/ml as a capture antibody.ELISA
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Gene Info — RGS2
Entrez GeneID
5997GeneBank Accession#
BC007049Protein Accession#
AAH07049Gene Name
RGS2
Gene Alias
G0S8
Gene Description
regulator of G-protein signaling 2, 24kDa
Omim ID
600861Gene Ontology
HyperlinkGene Summary
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq
Other Designations
G0 to G1 switch regulatory 8, 24kD|OTTHUMP00000033592|OTTHUMP00000060765|cell growth-inhibiting protein 31|regulator of G-protein signalling 2, 24kD|regulator of G-protein signalling 2, 24kDa
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Interactomes
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Diseases
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Publication Reference
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RGS2 Is Prognostic for Development of Castration Resistance and Cancer-Specific Survival in Castration-Resistant Prostate Cancer.
Anna Linder, Karin Larsson, Karin Welén, Jan-Erik Damber.
Prostate 2020 Aug; 80(11):799.
Application:WB-Ti, WB-Tr, Human, Orthotopic tumors of LNCaP cells.
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Analysis of regulator of G-protein signalling 2 (RGS2) expression and function during prostate cancer progression.
Linder A, Hagberg Thulin M, Damber JE, Welén K.
Scientific Reports 2018 Nov; 8(1):17259.
Application:WB, Human, LNCaP cells.
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Regulation of the regulator of G protein signaling 2 expression and cellular localization by PKA and PKC pathways in mouse granulosa cells.
Yeh HY, Sun D, Peng YC, Wu YL.
Biochemical and Biophysical Research Communications 2018 Sep; 503(2):950.
Application:WB-Ce, Mouse, NT-1 cells.
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Semi-quantitative measurement of specific proteins in human cumulus cells using reverse phase protein array.
Puard V, Tranchant T, Cadoret V, Gauthier C, Reiter E, Guerif F, Royere D.
Reproductive Biology and Endocrinology 2013 Oct; 11(1):100.
Application:WB-Ce, WB-Tr, Human, HEK 293 cells.
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Role of JAK2-STAT3 in TLR2-mediated tissue factor expression.
Park DW, Lyu JH, Kim JS, Chin H, Bae YS, Baek SH.
Journal of Cellular Biochemistry 2013 Jun; 114(6):1315.
Application:WB, Mouse, Raw264.7.
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RGS2 is a negative regulator of STAT3-mediated Nox1 expression.
Lee HK, Park DW, Bae JH, Kim HJ, Shin DG, Park JS, Lee JG, Lee SJ, Bae YS, Baek SH.
Cellular Signalling 2012 Mar; 24(3):803.
Application:WB-Tr, Mouse, Raw264.7 cells.
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Chromatin modifications induced by PML-RAR{alpha} repress critical targets in leukemogenesis as analyzed by ChIP-Chip.
Hoemme C, Peerzada A, Behre G, Wang Y, McClelland M, Nieselt K, Zschunke M, Disselhoff C, Agrawal S, Isken F, Tidow N, Berdel WE, Serve H, Muller-Tidow C.
Blood 2007 Nov; 111(5):2887.
Application:WB, Human, U937 cells.
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RGS2 Is Prognostic for Development of Castration Resistance and Cancer-Specific Survival in Castration-Resistant Prostate Cancer.
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