PTEN purified MaxPab mouse polyclonal antibody (B02P)
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More Files
- More Functions
Western Blot (Cell lysate)
PTEN MaxPab polyclonal antibody. Western Blot analysis of PTEN expression in HeLa.
Western Blot (Transfected lysate)
Western Blot analysis of PTEN expression in transfected 293T cell line (H00005728-T02) by PTEN MaxPab polyclonal antibody.
Lane 1: PTEN transfected lysate(44.33 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human PTEN protein.
Immunogen
PTEN (NP_000305.3, 1 a.a. ~ 403 a.a) full-length human protein.
Sequence
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
PTEN MaxPab polyclonal antibody. Western Blot analysis of PTEN expression in HeLa.Western Blot (Transfected lysate)
Western Blot analysis of PTEN expression in transfected 293T cell line (H00005728-T02) by PTEN MaxPab polyclonal antibody.
Lane 1: PTEN transfected lysate(44.33 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — PTEN
Entrez GeneID
5728GeneBank Accession#
NM_000314.4Protein Accession#
NP_000305.3Gene Name
PTEN
Gene Alias
10q23del, BZS, MGC11227, MHAM, MMAC1, PTEN1, TEP1
Gene Description
phosphatase and tensin homolog
Gene Ontology
HyperlinkGene Summary
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq
Other Designations
MMAC1 phosphatase and tensin homolog deleted on chromosome 10|OTTHUMP00000020032|mutated in multiple advanced cancers 1
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Interactome
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Pathway
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Disease
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