PSMD4 monoclonal antibody (M01), clone 3C9
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant PSMD4.
Immunogen
PSMD4 (NP_002801, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRII
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.84 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of PSMD4 expression in transfected 293T cell line by PSMD4 monoclonal antibody (M01), clone 3C9.
Lane 1: PSMD4 transfected lysate(40.7 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PSMD4 is 0.3 ng/ml as a capture antibody.ELISA
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Gene Info — PSMD4
Entrez GeneID
5710GeneBank Accession#
NM_002810Protein Accession#
NP_002801Gene Name
PSMD4
Gene Alias
AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5
Gene Description
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Omim ID
601648Gene Ontology
HyperlinkGene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq
Other Designations
26S protease subunit S5a|26S proteasome non-ATPase regulatory subunit 4|OTTHUMP00000014286|OTTHUMP00000059963|S5a/antisecretory factor protein|angiocidin|antisecretory factor 1|multiubiquitin chain binding protein|proteasome 26S non-ATPase subunit 4
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Interactome
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Pathway
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