MAP2K1 monoclonal antibody (M01), clone 1B5
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant MAP2K1.
Immunogen
MAP2K1 (NP_002746, 294 a.a. ~ 393 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
GRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (98); Rat (98)
Isotype
IgG1 kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of MAP2K1 expression in transfected 293T cell line by MAP2K1 monoclonal antibody (M01), clone 1B5.
Lane 1: MAP2K1 transfected lysate (Predicted MW: 43.439 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
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Gene Info — MAP2K1
Entrez GeneID
5604GeneBank Accession#
NM_002755Protein Accession#
NP_002746Gene Name
MAP2K1
Gene Alias
MAPKK1, MEK1, MKK1, PRKMK1
Gene Description
mitogen-activated protein kinase kinase 1
Omim ID
176872Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq
Other Designations
protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
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Interactome
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Pathway
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Disease
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Publication Reference
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ERK phosphorylation is dependent on cell adhesion in a subset of pediatric sarcoma cell lines.
Hye-Young Yoon, Ben Y Maron, Sofia Girald-Berlingeri, Anjelika Gasilina, Josephine C Gollin, Xiaoying Jian, Itoro Akpan, Marielle E Yohe, Paul A Randazzo, Pei-Wen Chen.
Biochimica et Biophysica Acta. Molecular Cell Research 2022 Aug; 1869(8):119264.
Application:WB-Ce, Human, RD, SMS-CTR cells.
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ERK phosphorylation is dependent on cell adhesion in a subset of pediatric sarcoma cell lines.
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